phase transition temperature of dotap

phase transition temperature of dotap

By continuing you agree to the use of cookies. In addition, the electronic friction has been introduced as a constant offset μ el, which vanishes well below the phase transition temperature T c. On the basis of this model, the relation between friction coefficient, temperature, and velocity above T c can be written as μ (v, T) = μ ph + μ el = [α − β T 2 / 3 (ln (γ T v) ) 2 / 3] + μ el Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Influence of charge density on bilayer bending rigidity in lipid vesicles: a combined dynamic light scattering and neutron spin-echo study.  |  2009;19(3):220-30. doi: 10.1080/08982100902746596. When antimony is deposited at room temperature on bismuth selenide, it forms domains of α-antimonene having different orientations with respect to the substrate. In copolymeric systems, the swelling process can be controlled by the introduction of the appropriate amount of a second monomer with hydrophobic and hydrophilic characters. We report the discovery of a temperature-induced phase transition between the α and β structures of antimonene. We find that the incorporation of increasing quantities of DOTAP progressively reduces the temperature and the enthalpy of the gel-to-liquid crystalline transition.  |  Transfection efficiencies of lipoplexes based on pure DOTAP analogs could be correlated with stability data and membrane fluidity at transfection temperature. Epub 2007 Sep 11. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Bordi F, Cametti C, Di Venanzio C, Sennato S, Zuzzi S. Colloids Surf B Biointerfaces. Thus, the heat capacity C p at the transition point is infinite. Biosphys. Remember that at the transition point, we are changing the enthalpy of the system but not its temperature. Epub 2013 Jul 17. Controlled formation and mixing of two-dimensional fluids. The Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib Anticancer Agents Med Chem. Liposomes composed of pure DOTAP analogs display characteristic temperature–anisotropy curves (or profiles) and in all cases, except for DSTAP, typical phase transition can be seen. Influence of temperature on microdomain organization of mixed cationic-zwitterionic lipidic monolayers at the air-water interface.  |  2A ), i.e. Acta 2001, 27, 1512.) DOTAP analogs were used as single components or combined with a helper lipid, either DOPE or cholesterol. limited to a DOTAP concentration below 20 mol %, confirm that the insertion of cationic head groups in zwitterionic phosphatidylcholine bilayers facilitates the formation of stable, relatively small, unilamellar vesicles. Addition of DOPE or cholesterol improved liposome and lipoplex stability. Get the latest research from NIH: https://www.nih.gov/coronavirus. NLM Epub 2013 Dec 1. Please enable it to take advantage of the complete set of features! Benesch MG, Mannock DA, Lewis RN, McElhaney RN. Stability of liposomes was a precondition for formation of temporarily stable lipoplexes. These results, which extend a previous investigation by Campbell et al. When anisotropy levels are high ( r >0.2; Fig. The phase transition temperature is defined as the temperature required to induce a change in the lipid physical state from the ordered gel phase, where the hydrocarbon chains are fully extended and closely packed, to the disordered liquid crystalline phase, where … Giatrellis S, Nikolopoulos G, Sideratou Z, Nounesis G. J Liposome Res. According to the measurements, photoanodes with 3% of SiO 2 result in improved efficiency, which is mainly related to increased surface area and dye loading. We use cookies to help provide and enhance our service and tailor content and ads. Calorimetric study of the interaction of binary DMTAP/DOTAP cationic liposomes with plasmid DNA. 2007 Jul;7(7):1980-4. doi: 10.1021/nl070726u. Phospholipid-cationic lipid interactions: influences on membrane and vesicle properties. 2001 May 2;1512(1):27-39. doi: 10.1016/s0005-2736(01)00290-5. Phase Transition Temperature Phase transition temperatures determined by DSC measurements were 25.3°C (enthalpy change, ΔΗ =34.1kJmol-1) and 29.1°C (ΔΗ =32.7kJmol-1) for aqueous vesicles of 1 and 2, respectively. We have investigated the effect of a cationic lipid [DOTAP] on both the thermotropic phase behavior and the structural organization of aqueous dispersions of dipalmitoyl-phosphatidylcholine [DPPC] by means of high-sensitivity differential scanning calorimetry and dynamic light scattering measurements. X-ray diffraction and Raman spectroscopy data show that anatase-to-rutile phase transition temperature is delayed by the presence of SiO 2, enabling single-anatase phase photoanodes for DSSCs. Inclusion of DOPE led to rather uniform transfection and anisotropy profiles, corresponding to lipoplex stability. Biochim Biophys Acta. This site needs JavaScript to work properly. The transition temperature can be altered by chemical interaction, e.g., via copolymerization, as the physical nature of the volume phase transition [13–16]. From: Studies in Surface Science and Catalysis, 2001 Reprinted with permission from John Wiley & Sons, Inc. Lipid Thermotropic Phase Transition Database (LIPIDAT) – NIST Standard Reference Database 34 Biophys J. Czolkos I, Erkan Y, Dommersnes P, Jesorka A, Orwar O. Nano Lett. USA.gov. Advisor: Dr. Sarah Keller Student: Jialing Li Phase Transition in Lipid Bilayers Ethanol’s Effect on Miscibility Transition Temperature in Ternary Vesicles Epub 2007 Jun 6. membranes show rigid character, there can also be found unstable liposomes. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. I want to ensure best formation of SUV’s from the LMV’s and LUV’s. These results, which extend a previous investigation by Campbell et al. Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius, Lipid-Protein Interactions, John Wiley & Sons, Inc., New York, 1982. 2011 Feb 16;100(4):875-84. doi: 10.1016/j.bpj.2010.11.049. In order to investigate the relationship between lipid structure and liposome-mediated gene transfer, we have studied biophysical parameters and transfection properties of monocationic DOTAP analogs, systematically modified in their non-polar hydrocarbon chains. 2014 Jan;177:71-90. doi: 10.1016/j.chemphyslip.2013.11.008. Effect of Tumor Relevant Acidic Environment in the Interaction of a N-hydroxyindole-2-Carboxylic Derivative with the Phospholipid Bilayer. We are further showing that, in mixed DOTAP-DPPC systems, the reduction of the phase transition temperature is accompanied by a reduction of the average size of the structures present in the aqueous mixtures, whatever the DOTAP concentration is.

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